Fibroblast Growth Factor 23: A Comprehensive Guide to Its Actions and Applications

Fibroblast Growth Factor 23 (FGF23) is a multifaceted protein that has garnered significant attention in the scientific community for its diverse roles in various biological processes. Initially identified as a bone-derived factor targeting the kidney, FGF23 has been found to have far-reaching effects on phosphate metabolism, receptor signaling, and beyond.

Complex Signaling Mechanisms and Tissue-Specific Effects

Research has shown that FGF23’s actions require distinct signaling receptors and mediators that differ among target tissues. This complexity is explored in-depth in this comprehensive book, which covers the latest findings on FGF23’s mechanisms and effects in various contexts.

Regulation of Phosphate Metabolism and Beyond

FGF23’s role in regulating phosphate metabolism is well-established, but its influence extends beyond this function. The book delves into novel concepts of FGF receptor signaling, shedding light on the intricacies of FGF23’s actions and their implications for our understanding of human physiology and disease.

Translational Research and Clinical Applications

This book brings together leaders in the field to discuss truly translational topics, from molecular signaling to physiology and mechanism of disease. The authors draw on their expertise in cell culture and animal models to study FGF23, providing valuable insights into its potential as a biomarker or drug target in the clinical setting.

Interdisciplinary Approaches and Expert Insights

The book features contributions from a diverse range of experts, including clinical and basic scientists with backgrounds in diseases, endocrinology, genetics, protein biochemistry, cell biology, and physiology. This interdisciplinary approach ensures a rich and nuanced understanding of FGF23’s complex effects and applications.

Publisher: Elsevier Science
Publication Date: April 6, 2021
Language: English
ISBN: 9780128180365, 9780128180372