The Regulatory Genome: Unraveling the Secrets of Adaptation, Evolution, Development, and Disease

Author Moyra Smith presents a comprehensive synthesis of recent genomic and gene expression studies across various organisms, including humans, plants, animals, and single-cell life. This groundbreaking book explores the crucial role of gene regulation in adaptive evolution, developmental biology, and disease susceptibility.

Unlocking the Secrets of Gene Regulation

The Regulatory Genome delves into the key elements of gene expression regulation, exploring the fundamentals of genomic alterations over time and in response to environmental and local conditions. The book sheds light on epigenetics in adaptive evolution and adaptive gene regulation in healthy processes, developmental biology, and disease biology.

A Comparative Approach to Understanding Evolutionary Themes

By adopting a cross-species approach, the book synthesizes recent sequencing and GWAS studies across organisms to highlight common evolutionary themes and genome diversity. This comparative analysis reveals fresh insights and identifies pathways for future research, ultimately informing our understanding of human adaptive evolution.

Illuminating the Impact of Gene Regulation on Disease and Health

The Regulatory Genome explores the significance of altered gene expression in developmental defects and disease, as well as its role in healthy biology and physiology. The book also examines our adaptive response to disease and its influence on disease outcomes, human metabolism, development, and physiology.

Key Features:

• Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines
• Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms
• Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology

Publisher: Elsevier Science | Language: English | ISBN: 9780443153525 | ISBN: 9780443153532 | Publication Date: March 10, 2023

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