Optimizing Oral Drug Delivery: A Comprehensive Review of Modified Release Formulations

Edited by renowned experts Edmund S. Kostewicz, Maria Vertzoni, Heather A. E. Benson, and Michael S. Roberts, “Oral Drug Delivery for Modified Release Formulations” is a cutting-edge resource that provides an in-depth exploration of the key aspects of oral absorption from modified-release (MR) dosage forms.

Understanding the Gastrointestinal Tract (GIT) and Oral Bioavailability

The book begins by delving into the complexities of the gastrointestinal tract (GIT) and the conditions that influence drug release and oral bioavailability. This essential knowledge provides a solid foundation for understanding the design and evaluation of MR formulations.

Designing Modified Release Formulations: From Early Drug Substance Testing to Biopharmaceutics Classification

The second section of the book focuses on the design of modified release formulations, covering critical topics such as:

• Early drug substance testing
• The biopharmaceutics classification system
• An array of formulation technologies for MR dosage forms
• And more

Evaluation and Regulatory Considerations for MR Formulations

The final section of the book concentrates on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations, including:

• Biorelevant dissolution testing
• Preliminary evaluation and physiologically-based pharmacokinetic modeling (PBPK) of in vivo behavior
• Regulatory guidelines from the US and EU

This comprehensive volume features contributions from leading researchers with expertise in the various aspects of MR formulations, providing:

• Authoritative coverage of physiology, physicochemical determinants, and in vitro-in vivo correlation (IVIVC)
• Clear explanations of different types of MR formulations and key terms used in the field
• Insights into the current status of MR technologies and identified gaps in research
• Industrial experiences and perspectives on the evaluation of MR dosage formulations

“Oral Drug Delivery for Modified Release Formulations” is an invaluable resource and guide for researchers, industrial scientists, and graduate students in the fields of drug delivery, pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Stay up-to-date with the latest developments in oral drug delivery and modified release formulations with this essential reference.