Neurotoxicity of Halogenated Organic Compounds: A Comprehensive Review (Volume 10)

Edited by renowned expert Lucio G. Costa, this latest volume delves into the neurotoxic effects of Halogenated Organic Compounds (HOCs), providing an in-depth exploration of three groups of legacy and emerging contaminants: Chlorinated, Brominated, and Fluorinated Compounds.

Understanding Halogenated Organic Compounds

Halogenated Organic Compounds are a class of chemicals found in various environmental sources, including air, water, and soil. They have been linked to various health risks, including neurotoxicity, and are a growing concern for both humans and wildlife. This volume provides a comprehensive overview of HOCs, covering their background, characteristics, physicochemical properties, environmental contamination, and human exposure.

Neurotoxic Effects of Halogenated Organic Compounds

The book is divided into several chapters, each focusing on specific aspects of HOC neurotoxicity. Topics covered include:

• Perspective on Halogenated Organic Compounds
• The Neurotoxicity of Polychlorinated Biphenyls (PCBs)
• Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs)
• Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR reality
• Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs)

Additional chapters explore the neuroendocrine effects of Brominated Flame Retardants (BFRs), focusing on Polybrominated Diphenyl Ethers (PBDEs), as well as the neurochemical effects of Halogenated Organic Compounds and their possible modes of action and structure-activity relationships.

Perfluoroalkyl Substances (PFAS) and Their Neurotoxic Effects

The volume also examines the neurotoxic effects of Perfluoroalkyl Substances (PFAS) in animal models and human cohorts, as well as the neurochemical mechanisms of PFAS neurotoxic action.

Future Directions and Regulatory Aspects

The book concludes with a discussion on future directions and regulatory aspects of Halogenated Organic Compounds, highlighting the need for continued research and policy implementation to mitigate the risks associated with these substances.

Providing the latest research on the neurotoxicity of Halogenated Organic Compounds, this comprehensive volume is an essential resource for researchers, policymakers, and environmental health professionals seeking to understand and address the health risks posed by these contaminants.

Publication Details:

• Publisher: Elsevier Science
• Publication Date: October 26, 2023
• Language: English
• ISBN: 9780443133404, 9780443133411