Understanding Multi-Drug Resistance in Cancer: A Comprehensive Guide

Author: Rishabha Malviya

Book Overview: The book delves into the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer, a leading cause of death worldwide, is often treated with chemotherapy. However, the development of multi-drug resistance (MDR) hinders the success of this treatment. This book aims to provide insights into the mechanisms of MDR and potential strategies to overcome it.

What is Multi-Drug Resistance?

Multi-drug resistance refers to the phenomenon where cancer cells develop resistance to multiple drugs, making chemotherapy less effective. It is estimated that drug resistance is responsible for 90% of cancer patient deaths. Prolonged chemotherapy often leads to refractory cancer and tumor recurrence due to the prevalence of drug-resistance mutations.

Key Topics Covered:

The book consists of nine chapters that explore various aspects of MDR, including:

• Studying the mechanics of resistance to drugs by autophagy
• Role of efflux transporters in drug resistance
• Expression of drug transporters and its implications
• Resistance to targeted therapies in breast cancer
• Advances in metallodrug driven combination treatment for cancer
• Use of natural agents for overcoming cancer drug resistance

Audience:

This book is intended for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in understanding the mechanisms of MDR and developing effective strategies to overcome it.

Publication Details:

Publisher: Wiley

Publication Date: July 4, 2023

Language: English

ISBN: 9781394209217, 9781394209859