Inducing Targeted Protein Degradation: A Comprehensive Guide for Drug Discovery

By Philipp Cromm, a renowned author in the field of drug discovery, this book provides a detailed insight into the groundbreaking technology of targeted protein degradation. Since the introduction of PROTAC technology in 2015, this approach has transformed the landscape of drug development, enabling researchers and pharmaceutical companies to explore novel therapeutic avenues.

Understanding the Basics of Targeted Protein Degradation

This book delves into the cellular mechanisms of targeted protein degradation, shedding light on how these mechanisms can be harnessed for drug discovery. It offers a comparative analysis of different degradation approaches, including PROTAC, molecular glues, LYTACs, ATTECs, and other post-translational modifications that are pivotal for drug development.

Drug Development and the Role of Targeted Protein Degradation

The book also explores the drug development aspects of targeted protein degradation, such as DMPK optimization and the criteria for selecting clinical candidates. It discusses the potential of this approach to expand the druggable space, providing drug discovery professionals and researchers with a practice-oriented reference on induced protein degradation.

Key Takeaways

Inducing Targeted Protein Degradation serves as a comprehensive guide for drug discovery professionals and researchers employing chemical biology approaches. It provides:

• Recent information on cellular mechanisms of targeted protein degradation and their application in drug discovery
• A detailed comparison of different induced degradation approaches
• Insights into drug development aspects, including DMPK optimization and clinical candidate selection
• A discussion on the potential of targeted degradation to expand the druggable space

Publication Details

Published by Wiley on November 9, 2022, this book is available in English. The ISBNs are 9783527350131 and 9783527350179.