Inducing Targeted Protein Degradation: A Comprehensive Guide for Drug Discovery

Inducing Targeted Protein Degradation is a groundbreaking guide for drug developers in academia and industry, providing insights into the latest advancements in drug discovery. This book focuses on the PROTAC technology, which has revolutionized the field since its breakthrough in 2015, enabling the development of novel therapeutics by expanding the range of accessible drug targets.

Understanding the Cellular Mechanisms of Targeted Protein Degradation

Readers will find the most recent information on cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery. This includes a detailed comparison of different induced degradation approaches such as PROTAC, molecular glues, LYTACs, and ATTECs, as well as additional post-translational modifications.

Drug Development Aspects and DMPK Optimization

The book also covers drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates. It discusses the potential of targeted degradation for expanding the druggable space, providing drug discovery professionals and researchers with a practice-oriented reference on induced protein degradation.

A Comprehensive Resource for Researchers and Professionals

Inducing Targeted Protein Degradation serves as a comprehensive resource for researchers employing chemical biology approaches and drug discovery professionals. It offers practical insights into the complexities of the subject and its practical application, helping to advance the field of drug discovery and expand the range of accessible drug targets.