Genomic and Epigenomic Biomarkers of Toxicology and Disease: A Comprehensive Guide

Genomic and Epigenomic Biomarkers of Toxicology and Disease is a cutting-edge compilation of the latest research in biomarker studies. This comprehensive guide is designed for researchers, toxicologists, risk assessors, and regulators, as well as graduate students interested in biomarkers, toxicology, agriculture, or the environment.

Introduction to MicroRNAs as Non-Invasive Biomarkers of Toxicity and Chemical Hazard

MicroRNAs are a class of non-coding RNAs that have emerged as promising biomarkers in toxicology and medicine. These small molecules can be easily measured in various biological fluids, making them ideal for non-invasive diagnostics. This section provides an in-depth exploration of microRNAs as biomarkers of toxicity and chemical hazard, highlighting their potential applications in early detection and prevention of diseases.

Extracellular Vesicle-Associated miRNAs as Toxic Biomarkers

Extracellular vesicles (EVs) are small, membrane-bound particles that are released by cells and can be found in various biological fluids. EVs contain a variety of biomolecules, including proteins, lipids, and nucleic acids, which can serve as biomarkers for various diseases. This section focuses on the role of EV-associated miRNAs as toxic biomarkers, discussing their potential applications in toxicology and medicine.

Transcriptomic Applications in Toxicology and Medicine

Transcriptomics is the study of the complete set of RNA transcripts produced by a cell or organism. This field has revolutionized our understanding of gene expression and its regulation. This section explores the applications of transcriptomics in toxicology and medicine, highlighting how this technology can be used to identify new biomarkers and understand the mechanisms of toxicity.

Circulating miRNAs as Biomarkers of Metal Exposure

Metal exposure is a significant environmental health concern, as metals can accumulate in the body and cause a range of adverse health effects. Circulating miRNAs have emerged as promising biomarkers for metal exposure, offering a non-invasive means of detecting and monitoring exposure levels. This section discusses the current state of research on circulating miRNAs as biomarkers of metal exposure, highlighting their potential applications in environmental health monitoring.

MicroRNAs Biomarkers of Malignant Mesothelioma

Malignant mesothelioma is a rare but aggressive form of cancer that is often associated with asbestos exposure. Early detection is critical for improving patient outcomes, but current diagnostic methods are limited. This section explores the potential of microRNAs as biomarkers for malignant mesothelioma, discussing recent research findings and future directions in this area.

Role of Noncoding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic

Environmental arsenic exposure is a significant public health concern, as this toxic metal can disrupt various cellular processes, including the immune system. Noncoding RNAs, such as microRNAs, have been implicated in the regulation of immune responses. This section examines the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic, highlighting the potential implications for human health.

Genomic and Epigenomic Biomarkers of Toxicology and Disease offers a comprehensive overview of the latest developments in biomarker research, providing insights into current trends and future directions in this rapidly evolving field. With contributions from internationally recognized investigators, this edited volume is an essential resource for anyone working in toxicology, medicine, or related fields.