Drug Disposition and Pharmacokinetics: A Comprehensive Guide

By Stephen H. Curry, a renowned author in the field of pharmacology, “Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology” is a leading reference that has been updated to provide the most current information on drug disposition and pharmacokinetics. This book serves as an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects.

A Balanced Approach

The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. It is an ideal reference for practicing professionals in industry as well as researchers and academics, assuming little prior knowledge.

New Edition, New Chapters

This latest edition provides readers with a new introductory chapter, as well as new chapters covering:

• Monoclonal antibodies
• The role of stereochemistry in drug disposition and pharmacokinetics
• DMPK in non-human species
• The recent use of AI in drug development

Comprehensive Coverage

Readers will also find thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling. In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PKPD modeling, are also included. Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies, are provided.

Real-World Applications

Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment, make this book a valuable resource for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology.

“Drug Disposition and Pharmacokinetics” will earn a place in the libraries of students of senior-level courses in pharmacy and related fields.