Neuronal Chloride Transporters: A Key to Understanding and Treating Neurological Diseases

Over the past few years, there has been a significant body of new research that has linked impairments in the expression or function of neuronal chloride transporters to a variety of diseases, including autism, epilepsy, depression, and more. This book provides an in-depth look at the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters, offering insights into the roles these transporters play in setting the transmembrane chloride gradient and regulating excitatory neurotransmission.

Understanding Neuronal Chloride Transporter Biology

Neuronal chloride transporters are crucial for maintaining the proper balance of chloride ions within neurons. The KCC and NKCC families of transporters are responsible for regulating the transmembrane chloride gradient, which is essential for the proper functioning of inhibitory and excitatory neurotransmission. This book reviews the current understanding of the molecular and cellular biology of these transporters, including their structure, post-translational modification, membrane trafficking, and protein interaction partners.

Linking Neuronal Chloride Transporter Deficiencies to Disease

Research has shown that deficiencies in neuronal chloride transporters are implicated in a range of neurological diseases, including autism, epilepsy, depression, and pain, as well as brain and spinal cord injury. This book explores the genetic and environmental factors that regulate the expression of these transporters in neurons and discusses the potential therapeutic approaches that target neuronal chloride transporters to treat these diseases.

Emerging Topics in Neuronal Chloride Transporter Research

This book also provides an overview of some of the key emerging topics in the field of neuronal chloride transporter research, including the development of new drugs that target these transporters for the treatment of nervous system diseases. With its comprehensive coverage of the latest advances in the field, this volume is an essential resource for researchers, clinicians, and students seeking to understand the complex roles of neuronal chloride transporters in health and disease.