Understanding Neuronal Chloride Transporters: A Key to Unlocking the Mysteries of the Nervous System

Over the past few years, groundbreaking research has emerged, linking impairments in the expression or function of neuronal chloride transporters to a myriad of diseases, including autism, brain aging, and more. This comprehensive guide delves into the core concepts and recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters.

Neuronal Chloride Transporter Biology: An Overview

Neuronal chloride transporters play a pivotal role in setting the transmembrane chloride gradient and regulating excitatory neurotransmission. This section of the book provides an in-depth look at the biology of these transporters, shedding light on their chloride transport-independent functions and their impact on the nervous system.

Structure, Post-Translational Modification, and Membrane Trafficking of Neuronal Chloride Transporters

This chapter is dedicated to the molecular and cellular biology of neuronal chloride transporters. It covers the structure, post-translational modification, and membrane trafficking of these transporters, as well as their protein interaction partners and the genetic and environmental factors that regulate their expression in neurons.

Neuronal Chloride Transporter Deficiencies and Their Impact on Health

Deficiencies in neuronal chloride transporters have been implicated in a range of neurological disorders, including autism, epilepsy, depression, and more. This section of the book explores the role of these deficiencies in various health conditions, including pain and brain and spinal cord injury.

Targeting Neuronal Chloride Transporters for Nervous System Diseases: A Promising Therapeutic Approach

Finally, this book discusses the potential therapeutic approaches that target neuronal chloride transporters to treat nervous system diseases. It highlights the ongoing drug research in this area and the potential benefits of these treatments for patients suffering from neurological disorders.