Molecules Engineered Against Oncogenic Proteins and Cancer: A Comprehensive Review

Author: E. J. Corey

Overview: Molecules Engineered Against Oncogenic Proteins and Cancer is a comprehensive review of the latest molecular advances in cancer treatment. The book documents the recent scientific advances that have transformed one of medicine’s most challenging areas – cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented.

Key Features:

• Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action.
• Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent.
• History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer.
• The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field.

Target Audience:

This book is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.

Publication Details:

Publisher: Wiley

Publication Date: August 9, 2023

Language: English

ISBN: 9781394207084, 9781394207091