TDP-43 and Neurodegeneration: From Bench to Bedside

Aggregates of the TAR DNA binding protein 43 (TDP-43) are a hallmark feature of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic, and pathological features. This book, “TDP-43 and Neurodegeneration: From Bench to Bedside,” provides a comprehensive overview of new findings in TDP-43 pathobiology and proteinopathies.

Understanding TDP-43

TDP-43 is a protein that plays a crucial role in various cellular processes, including transcription, splicing, and translation. Its misfolding and aggregation are implicated in the pathogenesis of ALS and FTD. The book delves into the structure, function, biology, misfolding, aggregation, pathogenesis, and therapeutics of TDP-43.

Therapeutic Approaches

The book discusses various therapeutic approaches targeting TDP-43 proteinopathies, including autophagy-mediated therapy, the role of stress granules, novel genetic and cell culture-based models, systems biology for precision medicine, and the development of stem cells and mechanism-based therapies. These approaches aim to provide potential treatments for ALS and other related neurodegenerative diseases.

Target Audience

This book is an essential resource for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, and cellular and molecular biologists involved in ALS, motor neuron disease (MND), and other neurodegenerative disorders. It provides a comprehensive understanding of TDP-43’s role in neurodegeneration and its potential therapeutic applications.

Key Features

The book reviews TDP-43’s structure, folding, function, and pathology, identifying its role in ALS, FTD, and other neurodegenerative diseases. It presents a systems and precision biology perspective of TDP-43 and discusses therapeutics of TDP-43 proteinopathies, translating bench research to bedside applications.

Publication Details

Published by Elsevier Science, this book is available in English and was released on October 23, 2021. The ISBNs for the book are 9780128200667 and 9780128204405.