From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

Volume 88 of the Advances in Pharmacology series, authored by Christopher J. Langmead, presents a comprehensive compilation of chapters from leading experts in the field. This updated edition delves into the latest research and advancements in the field of G Protein-Coupled Receptors (GPCRs) and their role in various diseases.

Targeting Muscarinic M1 Receptor in Neurodegeneration

This chapter explores the potential therapeutic benefits of targeting the muscarinic M1 receptor in neurodegenerative disorders, shedding light on the receptor’s role in cognitive functions and its potential as a drug target.

Photo-Switchable Allosteric Ligands

This section discusses the development and application of photo-switchable allosteric ligands, which can be controlled by light, offering a new dimension in the study and manipulation of GPCRs.

Computational Approaches for the Design of mGlu Receptor Allosteric Modulators

This chapter highlights the use of computational tools and methods in the design and development of mGlu receptor allosteric modulators, providing insights into the structure-function relationship of these receptors.

Allosteric Modulation of GLP-1 Receptor in Metabolic Disorders

This section delves into the role of GLP-1 receptor allosteric modulation in the treatment of metabolic disorders, including diabetes and obesity, and discusses the potential therapeutic benefits of targeting this receptor.

Group II mGluR Roles in the Nervous System and Their Roles in Addiction

This chapter examines the functions of Group II mGluRs in the nervous system, with a particular focus on their involvement in addiction and the potential for these receptors as therapeutic targets.

RAMPs as Allosteric Modulators of Class B GPCRs

This section explores the role of Receptor Activity-Modifying Proteins (RAMPs) in the regulation of Class B GPCRs, highlighting their potential as therapeutic targets for various diseases.

Structure-Based Discovery and Development of mGlu5 NAMs

This chapter discusses the structure-based approach to the discovery and development of negative allosteric modulators (NAMs) for the mGlu5 receptor, a potential therapeutic target for various neurological disorders.

By presenting the latest research and advancements in the field of G Protein-Coupled Receptors, this book serves as a valuable resource for researchers, scientists, and students working in the field of pharmacology and related disciplines.