Advances in Pharmacology, Volume 91: A Comprehensive Guide to the Latest in the Field

Authored by Cheryl Rockwell, this latest volume in the well-received Advances in Pharmacology series presents the most recent advancements in the field of pharmacology. The book includes a wide range of topics, from the modulation of inflammation and immune response by the stress-activated transcription factor Nrf2, to the therapeutic targeting of tumor-associated macrophages, mast cells, and more.

Modulation of Inflammation and Immune Response by Nrf2

This chapter delves into the role of Nrf2 in modulating inflammation and immune response. Nrf2, a transcription factor, plays a crucial role in the regulation of oxidative stress and inflammation. The chapter discusses how Nrf2 can be therapeutically targeted to treat various diseases.

Therapeutic Modulation of Macrophage Phenotype

This section focuses on the therapeutic modulation of macrophage phenotype to treat acute and chronic liver diseases. Macrophages play a key role in the immune system, and their phenotype can significantly impact disease progression. The chapter explores various strategies for modulating macrophage phenotype for therapeutic purposes.

Immodulation by Cannabinoids

This chapter discusses the effects of cannabinoids on the immune system. Cannabinoids, found in the cannabis plant, have been shown to have both immunosuppressive and immunostimulatory effects, depending on the context. The chapter reviews the current understanding of cannabinoid immunomodulation and its potential therapeutic applications.

The Use of Nanomaterials to Target Immunity

This section covers the use of nanomaterials to target the immune system. Nanomaterials have the potential to revolutionize the field of immunotherapy by providing targeted and efficient delivery of immunomodulatory agents. The chapter discusses the current state of nanomaterial-based immunotherapies and their future prospects.

Next Generation in Cancer Immunotherapy

This chapter reviews the next generation of cancer immunotherapies, focusing on checkpoint inhibitors. Checkpoint inhibitors have shown significant promise in treating various types of cancer by enhancing the immune response against tumor cells. The chapter discusses the mechanisms of action, clinical trials, and future directions for these therapies.

Vaccines as a Therapy for Food Allergy

This section explores the potential of vaccines as a therapy for food allergy. Food allergies are a growing public health concern, and current treatments are limited. The chapter discusses various vaccine strategies being developed to prevent and treat food allergies.

Role of Inflammation/Immune System in Depression

This chapter examines the role of inflammation and the immune system in depression. There is growing evidence that inflammation and immune dysregulation contribute to the pathogenesis of depression. The chapter reviews the current understanding of this relationship and potential therapeutic strategies.

Therapeutic Targeting of Tumor-Associated Macrophages

This section focuses on the therapeutic targeting of tumor-associated macrophages. Tumor-associated macrophages can promote tumor growth and metastasis, making them an attractive target for cancer therapy. The chapter discusses various strategies for targeting these cells.

Mast Cells in Disease

This final chapter reviews the role of mast cells in various diseases. Mast cells are key players in the immune system, involved in both protective and pathological responses. The chapter covers the current understanding of mast cell biology and their involvement in diseases such as asthma, autoimmune disorders, and cancer.