Dystonia: A Comprehensive Review of Clinical Features, Genetics, and Treatment Options

Author: Hyder Jinnah

Publication Date: July 26, 2023

ISBN: 9780323990264, 9780323990271

Language: English

Published By: Elsevier Science

Series: International Review of Neurobiology, Volume 169

Overview: This latest release in the International Review of Neurobiology series, Dystonia, Volume 169, provides a comprehensive overview of the latest advances in the field of dystonia. The book features a collection of chapters that delve into various aspects of dystonia, including clinical features, genetic pathways, and treatment options.

Key Topics Covered:

Clinical Features and the Science of Classification: This chapter explores the different clinical features of dystonia and the various classification systems used to understand the disorder.

What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia: This section discusses the insights gained from epidemiological studies on the neurobiology of dystonia, shedding light on the prevalence, risk factors, and underlying mechanisms of the condition.

Dystonia Genes and Their Biological Pathways: This chapter delves into the genetic aspects of dystonia, covering the identified genes associated with the disorder and their biological pathways.

Functional Anatomy of Dystonia: This section provides an in-depth look at the functional anatomy of dystonia, focusing on the brain regions and networks involved in the disorder.

Physiology of Dystonia: Human Studies: This chapter presents findings from human studies on the physiology of dystonia, including neurophysiological and neuroimaging investigations.

Physiology of Dystonia: Animal Studies: This section discusses the results of animal studies on the physiology of dystonia, which have contributed significantly to our understanding of the disorder’s underlying mechanisms.

Experimental Pharmacology: Targeting Neurotransmitters: This chapter reviews the experimental pharmacological approaches aimed at targeting neurotransmitters in the treatment of dystonia.

Experimental Pharmacology: Targeting Metabolic Pathways: This section explores the experimental pharmacological strategies focused on targeting metabolic pathways for the treatment of dystonia.

Adult-Onset Focal Dystonias: One Biology or Many?: This chapter addresses the question of whether adult-onset focal dystonias share a common biology or represent distinct entities.

Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?: This section compares and contrasts the biological mechanisms underlying early-onset inherited and late-onset idiopathic dystonias.

Conclusion: Dystonia, Volume 169, offers a comprehensive and up-to-date review of the clinical features, genetic aspects, and treatment options for dystonia. This book is an essential resource for researchers, clinicians, and students seeking to understand the complexities of this disorder and the latest advances in the field.