Unveiling Epigenetics in Human Disease: A Comprehensive Guide

Edited by renowned expert Trygve O. Tollefsbol, the third edition of Epigenetics in Human Disease presents a thorough examination of the complex relationships between epigenetic mechanisms and various human diseases. This comprehensive guide delves into the latest research on epigenetics, discussing its applications in understanding and treating a wide range of diseases and disorders.

Exploring the Epigenetic Landscape of Human Disease

This extensively revised edition covers a broad spectrum of topics, including:

• Cancer: epigenetic mechanisms and therapeutic interventions
• Autoimmune disorders: the role of epigenetics in disease development and treatment
• Aging: epigenetic changes and their implications for healthspan
• Metabolic disorders: the epigenetic link to obesity, diabetes, and cardiovascular disease
• Neurobiological disorders: the epigenetic basis of neurological diseases such as Alzheimer’s and Parkinson’s
• Cardiovascular disease: epigenetic risk factors and therapeutic targets

Advances in Epigenetic Research and Clinical Translation

This edition features in-depth discussions on cutting-edge topics, including:

• Stem cell epigenetic therapy: harnessing epigenetics for regenerative medicine
• Bioinformatic analysis of NGS data: unlocking the potential of epigenomic data
• Epigenetic mechanisms of imprinting disorders: new insights into developmental biology
• MicroRNA in cancer: the role of non-coding RNAs in tumor biology
• Epigenetic approaches to control obesity, airway disease, and cardiovascular disease

Tools and Resources for Epigenetic Research

The book also provides an overview of online epigenetic tools and datasets, empowering researchers and clinicians to integrate epigenetics into their work. Additionally, it explores the epigenetics of addiction, suicide, and early-life programming in age-related diseases.

Contributions from Leading Experts

This comprehensive guide features contributions from renowned international investigators involved in translational epigenetic research and therapeutic applications. Their expertise provides a unique perspective on the applications of epigenetics in human disease, bridging the gap between fundamental research and clinical practice.

Enhanced Learning and Visualization

Each chapter includes:

• Chapter summaries for quick review
• Definitions for clarity and understanding
• Vibrant imagery and figures to illustrate complex concepts
• Step-by-step methods and disease research case studies for practical application

This extensively revised edition of Epigenetics in Human Disease is an indispensable resource for researchers, clinicians, and students seeking to understand the intricate relationships between epigenetics and human disease.