Protein Toxicity in Food and Pharmaceuticals: A Comprehensive Guide

Human health relies heavily on access to high-quality proteins for a balanced diet and pharmaceutical applications. However, certain proteins can be toxic to individuals with sensitivities, while others can become toxic due to mutations or aggregation.

The Paradox of Protein Toxicity

Some proteins, like glutens and allergens, are valuable food sources but can be harmful to those with sensitivities. Even proteins produced within the human body can become toxic, as seen in Alzheimer’s and Huntington’s diseases, which are characterized by insoluble protein aggregations in the brain.

Ironically, toxins produced by pathogenic microorganisms, such as Botox, have found use in the clinic and industry. Meanwhile, proteins like interferons and cytokines can be valuable therapeutics, but are also associated with autoimmune diseases like psoriasis and lupus erythematosus.

Key Features of Protein Toxicity

• Discusses the unique properties of gluten proteins and their impact on symptoms in those with celiac disease.
• Explores the concept of “multiple allergy syndrome” and its relation to similar allergens in diverse plants.
• Examines the challenges of using human proteins and cytokines as therapeutics.
• Highlights the role of protein aggregates in physiological processes and their characterization in renal and neurological syndromes.
• Provides examples of protein toxins with medical and industrial applications.

Related Resources

For further exploration of protein concepts and their applications, consider the following titles:

• “Proteins: Concepts in Biochemistry” by P. Almeida
• “How Proteins Work” by M. Williamson
• “Food Allergy: Molecular and Clinical Practice” edited by A. L. Lopata
• “Alzheimer’s Disease: Targets of New Clinical Diagnostic and Therapeutic Strategies” edited by R. D. Wegrzyn and A. S. Rudolph

This comprehensive guide, published by CRC Press, is available in English and can be identified by the following ISBN numbers: 9781032366937 and 9781000959789.