Multidrug Resistance in Cancer: Understanding the Mechanisms and Strategies for Overcoming

Cancer remains a significant threat to human life, accounting for millions of deaths worldwide. Despite the advancements in cancer treatment, chemotherapy remains a cornerstone of modern cancer therapy. However, the development of multidrug resistance (MDR) in cancer cells hinders the effectiveness of chemotherapy, leading to refractory cancer and tumor recurrence.

The Menace of Multidrug Resistance in Cancer

MDR is a complex phenomenon where cancer cells develop resistance to multiple anticancer drugs, resulting in treatment failure. According to alarming statistics, drug resistance is responsible for 90% of cancer patient deaths. The emergence of MDR is attributed to the genomic instability of cancer cells, which leads to the development of resistant clones.

Understanding the Mechanisms of Multidrug Resistance in Cancer

Elucidating the mechanisms underlying MDR is crucial for the development of effective cancer therapies. The book “Multidrug Resistance in Cancer: Mechanism and Treatment Strategies” delves into the intricacies of MDR, covering topics such as:

• The role of autophagy in drug resistance
• The expression and function of efflux transporters
• Resistance to targeted therapies in breast cancer
• Advances in metallodrug-driven combination treatment for cancer
• The use of natural agents in overcoming cancer drug resistance

A Comprehensive Guide for Cancer Researchers and Practitioners

This book is an indispensable resource for pharmaceutical and biomedical scientists, researchers, and clinicians seeking to understand the mechanisms and strategies for overcoming MDR in cancer. By providing the latest insights into the mechanisms of cellular resistance to anticancer agents, this book aims to facilitate the development of novel and effective cancer treatment strategies.

Key Features:

• Covers the latest research on multidrug resistance in cancer
• Explores the mechanisms of MDR and targets of novel chemotherapy agents
• Provides a comprehensive understanding of the strategies for overcoming MDR in cancer
• A valuable resource for cancer researchers, clinicians, and students

Stay updated with the latest advancements in cancer research and treatment strategies. Dive into the complexities of multidrug resistance in cancer and explore the latest insights into overcoming this significant barrier to effective cancer treatment.