Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders: A Comprehensive Guide

By Heba Mohamed Mansour, Mahmoud Mohamed Khattab, and Aiman Saad El-Khatib

The overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer, and recent evidence suggests that dysregulation of RTKs is also reported in many neurodegenerative and psychiatric disorders. This book provides a fundamental and pragmatic overview of RTKs, covering their structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in the developing central nervous system (CNS), adult normal CNS, neurodegenerative disorders, and psychiatric disorders.

Comprehensive Coverage of RTKs in Neurodegenerative Disorders

The book offers a comprehensive discussion of the results of pre-clinical and clinical studies of repositioning anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders, including:

• Alzheimer’s disease
• Parkinson’s disease
• Amyotrophic lateral sclerosis (ALS)
• Huntington’s disease
• Multiple sclerosis

Coverage of RTKs in Psychiatric Disorders

In addition, the book covers the role of RTKs in psychiatric disorders, including:

• Anxiety
• Depression
• Alcohol use disorder
• Schizophrenia

Expert Insights and Future Directions

The book features chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology, providing a thorough overview of RTKs biology and their role in health and disease progression and modulation. It also highlights RTK families and the numerous receptors within each subfamily, examining RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials.

The book concludes by discussing the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders, and provides future directions for possible safe and effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in these disorders.

Product Details: This 604-page paperback, published by Academic Press, provides a valuable resource for researchers, clinicians, and students interested in the role of RTKs in neurodegenerative and psychiatric disorders.

Publication Date: June 22, 2023

Language: English

ISBN-10: 0443186774

ISBN-13: 978-0443186776