The Textbook of Ion Channels: A Comprehensive Guide

Authored by Jie Zheng and Matthew C. Trudeau, this three-volume set provides an exhaustive reference source on ion channels for students, instructors, and researchers.

The Importance of Ion Channels

Ion channels are membrane proteins that play a crucial role in controlling the electrical properties of neurons and cardiac cells. They mediate the detection and response to sensory stimuli, such as light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. Moreover, ion channels are instrumental in maintaining basic salt balance, which is critical for homeostasis in non-excitable tissues.

Ion channels are located on the surface membrane of cells, allowing them to communicate with the environment, and on the membrane of intracellular organelles, enabling them to regulate internal homeostasis. Their dysfunction is implicated in various human diseases, making them important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain, and other clinical applications.

Volume III: Key Ion Channel Regulators and Mechanisms

This volume delves into the critical aspects of ion channel regulation, including splice variants, calcium-calmodulin regulation, regulation by G proteins, and lipids. It also explores the role of ion channels in selected physiological systems, such as the heart, immune cells, pancreatic beta cells, and sperm and eggs.

Furthermore, Volume III provides an in-depth examination of ion channel mutations and dysfunction in diseases like epilepsy, cystic fibrosis, and pain syndromes.

A Comprehensive Resource for Ion Channel Research

This three-volume set offers a comprehensive introduction to the fundamental concepts necessary to understand the mechanism of ion channels. It serves as a guide to the technical aspects of ion channel research, provides a modern guide to the properties of major ion channel families, and includes coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Published by CRC Press, this first edition was released on June 28, 2023. The hardcover edition consists of 234 pages and has an ISBN-10 of 0367538199 and an ISBN-13 of 978-0367538194.