Unlock the Secrets of Ion Channels: A Comprehensive Reference Guide

Authored by Jie Zheng and Matthew C. Trudeau, The Textbook of Ion Channels is a three-volume masterpiece that provides an exhaustive reference source for students, instructors, and researchers. This extensive resource delves into the intricate world of ion channels, membrane proteins that play a crucial role in regulating the electrical properties of neurons and cardiac cells.

The Importance of Ion Channels in Human Health and Disease

Ion channels are not only essential for detecting and responding to sensory stimuli like light, sound, odor, and taste but also regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, they are vital for maintaining basic salt balance, which is critical for homeostasis. Their dysfunction has been implicated in various human diseases, making them important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain, and other clinical applications.

Modern Methods and Techniques in Ion Channel Research

The study of ion channels employs a range of powerful and diverse methods, from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs. This multidisciplinary approach has greatly advanced our understanding of these complex proteins.

Volume III: Ion Channel Regulators, Physiological Systems, and Diseases

The third volume of The Textbook of Ion Channels focuses on key ion channel regulators and their mechanisms, the role of ion channels in selected physiological systems, and examples of ion channel mutations and dysfunction in various diseases. It covers topics such as:

• Ion channel regulation by splice variants, calcium-calmodulin, G proteins, and lipids
• The role of ion channels in the heart, immune cells, pancreatic beta cells, and sperm and eggs
• Ionic channel dysfunctions in epilepsy, cystic fibrosis, and pain syndromes

Throughout the three volumes, readers will gain a comprehensive understanding of the fundamental concepts, technical aspects, and properties of major ion channel families, as well as their regulatory, physiological, and disease roles.

Book Details

Published by CRC Press, the first edition of The Textbook of Ion Channels was released on June 28, 2023. This 234-page hardcover book is written in English and can be identified by its ISBN-10: 0367538199 and ISBN-13: 978-0367538194.