Unlock the Secrets of Ion Channels: A Comprehensive Reference Guide

Edited by renowned experts Jie Zheng and Matthew C. Trudeau, The Textbook of Ion Channels is a groundbreaking three-volume set that provides an unparalleled reference source for students, instructors, and researchers in the field of ion channels.

The Importance of Ion Channels in Human Health and Disease

Ion channels are membrane proteins that play a crucial role in regulating various physiological processes, including the electrical properties of neurons and cardiac cells, sensory perception, and salt balance in non-excitable tissues. These proteins are essential for human health and are implicated in numerous diseases, making them a crucial target for pharmaceuticals in mental illness, heart disease, anesthesia, pain, and other clinical applications.

A Comprehensive Overview of Ion Channel Research

The modern methods used to study ion channels are diverse and powerful, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs. This textbook provides a comprehensive overview of the field, covering fundamental topics such as:

• Basic principles of ion permeation and selectivity
• Voltage-dependent, ligand-dependent, and mechano-dependent ion channel activation mechanisms
• Mechanisms for ion channel desensitization and inactivation, and basic ion channel pharmacology and inhibition

Practical Guidance for Ion Channel Research

Volume I, Part 2 offers a practical guide to researching ion channels, including:

• Heterologous expression and voltage-clamp and patch-clamp electrophysiology
• Isolation of native currents using patch clamping
• Modeling ion channel gating, structures, and dynamics
• Crystallography and cryo-electron microscopy
• Fluorescence and paramagnetic resonance spectroscopy methods
• Genetics approaches in model organisms

A Valuable Resource for Ion Channel Researchers

This comprehensive textbook provides readers with a solid foundation in the fundamental concepts of ion channels, as well as practical guidance on the technical aspects of ion channel research. The three-volume set covers the properties of major ion channel families, regulatory, physiological, and disease roles for ion channels, and more.

The Textbook of Ion Channels is an essential resource for anyone interested in ion channel research, providing a comprehensive and authoritative guide to this complex and rapidly evolving field.

Product Details:

• Publisher: CRC Press
• Edition: 1st
• Publication Date: June 9, 2023
• Language: English
• Pages: 318
• ISBN-10: 0367538156
• ISBN-13: 978-0367538156