Unlock the Secrets of Ion Channels: A Comprehensive Reference Source

Authored by esteemed experts Jie Zheng and Matthew C. Trudeau, The Textbook of Ion Channels is a three-volume masterpiece providing an in-depth exploration of these crucial membrane proteins. Ion channels play a vital role in regulating the electrical properties of neurons and cardiac cells, mediating sensory stimuli detection and response, and controlling the body’s response to physical stimuli.

The Importance of Ion Channels in Human Health and Disease

Ion channels are situated at the surface membrane of cells, enabling them to communicate with the environment and regulate internal homeostasis. Their dysfunction is linked to various diseases, making them a critical target for pharmaceuticals in mental illness, heart disease, anesthesia, pain, and other clinical applications.

Volumes I, II, and III: A Detailed Exploration of Ion Channels

Volume I, Part 1 delves into the fundamental principles of ion permeation and selectivity, voltage-dependent, ligand-dependent, and mechano-dependent ion channel activation mechanisms, as well as ion channel desensitization and inactivation. Additionally, it covers basic ion channel pharmacology and inhibition.

Volume I, Part 2 serves as a practical guide for researchers, offering insight into cardinal methods for studying ion channels. These include heterologous expression and voltage-clamp and patch-clamp electrophysiology, isolation of native currents using patch clamping, modeling ion channel gating, structures, and dynamics, crystallography and cryo-electron microscopy, fluorescence and paramagnetic resonance spectroscopy methods, and genetics approaches in model organisms.

The three-volume set provides readers with a comprehensive understanding of ion channels, covering fundamental concepts, technical aspects of research, properties of major ion channel families, and their regulatory, physiological, and disease roles.

Product Details:

Publisher: CRC Press

Edition: 1st edition (June 9, 2023)

Language: English

Hardcover: 318 pages

ISBN-10: 0367538156

ISBN-13: 978-0367538156

Stay ahead in the field of ion channel research with this exhaustive reference source, providing insights into the mechanisms, technical aspects, and applications of these vital membrane proteins.