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Current treatment concepts for primary CNS lymphoma (UNI-MED Science) (Original PDF from Publisher)

Primary CNS Lymphomas: A Comprehensive Overview

Authored by Gerald Illerhaus and Elisabeth Schorb, this monograph delves into the intricacies of Primary Central Nervous System Lymphomas (PCNSLs), a rare and aggressive type of non-Hodgkin lymphoma.

Definition and Prevalence

PCNSLs are defined as lymphomas that exclusively affect the brain parenchyma, meninges, spinal cord, or vitreoretinal area at the time of diagnosis. These tumors occur more frequently in immunoincompetent patients than in immunocompetent individuals.

Characteristics and Prognosis

Primary CNS Lymphomas are typically diffuse large-cell B-cell lymphomas, characterized by aggressive behavior and a median survival time of only a few weeks to months without treatment. However, they respond well to chemotherapy, offering a promising prognosis with timely intervention.

Therapeutic Challenges and Advancements

The blood-brain barrier poses a significant obstacle in PCNSL treatment. Despite this, researchers have made significant strides in developing curative therapeutic approaches, including induction and consolidation therapy. These innovative strategies have achieved high remission rates and prolonged progression-free survival.

A Compact and Informative Resource

This monograph condenses the latest knowledge on PCNSLs into a comprehensive and accessible guide. By exploring the complexities of this rare tumor disease, readers can gain a deeper understanding of its diagnosis, treatment, and management.

Key details about this publication include:

  • Publisher: UNI-MED Verlag AG
  • Edition: 1st edition
  • Publication date: April 8, 2021
  • Language: English

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