Understanding Pancreatic Cancer: Advances in Basic Mechanisms and Therapies

By Luni Emdad, Azeddine Atfi, Rajan Gogna, Jose G Trevino, Paul B. Fisher

Volume 159 in the Advances in Cancer Research presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research.

Introduction to Pancreatic Cancer

Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment.

Advances in Understanding PDAC Pathogenesis and Therapies

Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC.

Key Topics Covered in the Thematic Issue

In this thematic issue, we have included ten review articles by experts that cover:

• Cancer disparities
• PDAC pathobiology
• The roles of the tumor microenvironment
• Tumor heterogeneity
• PC stem cells
• Genetic and signaling events critical for PDAC pathogenesis
• Immunotherapy and chemoresistance in PDAC
• Different PDAC mouse models

Significance of the Thematic Issue

This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research. It provides a comprehensive overview of the current understanding of PDAC pathogenesis and the development of new therapeutic strategies.

Target Audience

This thematic issue is designed for researchers, oncologists, and healthcare professionals interested in understanding the latest advances in PDAC research and its implications for patient care.

Publication Details

Publication Date: June 15, 2023

Pages: 390

ISBN-10: 0443133549

ISBN-13: 978-0443133541

Language: English

Format: Hardcover