Understanding and Managing Drug-Induced Liver Injury (DILI): A Comprehensive Guide

By Pierre Gholam MD AGAF FAASLD, in collaboration with Consulting Editor, Dr. Norman Gitlin, this book provides a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics:

Epidemiology, Predisposing Factors and Outcomes

Learn about the incidence and prevalence of DILI, as well as the factors that predispose individuals to this condition and the potential outcomes.

Genetic Predisposition to DILI

Discover the genetic factors that may increase an individual’s risk of developing DILI and how genetic testing can aid in early detection and prevention.

Causality Assessment Frequent Offenders and Patterns of Injury

Understand the common drugs that cause DILI, the patterns of liver injury they produce, and how to assess causality in patients presenting with liver damage.

Quantitative Systems Toxicology Approaches to Understand and Predict DILI

Explore the use of quantitative systems toxicology to predict and understand DILI, including the role of computational models and biomarkers in risk assessment.

Liver Histology: Diagnostic and Prognostic Features

Examine the diagnostic and prognostic features of liver histology in DILI, including the different types of liver damage and their implications for patient outcomes.

Acute Liver Failure Secondary to DILI

Learn about the management and treatment of acute liver failure resulting from DILI, including the role of liver transplantation.

DILI in Persons with Pre-existing Chronic Liver Disease

Understand the unique challenges and considerations in managing DILI in patients with pre-existing chronic liver disease.

DILI in the Setting of Statin Use

Examine the relationship between statin use and DILI, including the risk factors and management strategies for patients on statin therapy.

DILI in the Setting of Analgesic Use

Explore the risk of DILI associated with the use of various analgesics, including acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs).

DILI Secondary to Herbals and Dietary Supplements

Learn about the risk of DILI from the use of herbal and dietary supplements, including the common products implicated and strategies for prevention and management.

DILI Reporting and Resources for the Clinician

Find out about the importance of reporting DILI cases and the resources available to clinicians for managing and treating patients with DILI.