Advances in Cancer Research: miRNA and Cancer, Volume 135

Edited by Paul B Fisher and Carlo Croce, with contributions from renowned experts in the field, this latest volume in the Advances in Cancer Research series delves into the rapidly evolving landscape of cancer research, focusing on the intricate relationship between oncology and gene expression.

Non-coding RNAs as Biomarkers of Cancer

This chapter explores the role of non-coding RNAs as potential biomarkers for cancer diagnosis and treatment monitoring. It discusses the various types of non-coding RNAs, their functions, and the challenges and opportunities in utilizing them as biomarkers.

The Enigma of microRNA Regulation in Cancer

This section delves into the complex and often paradoxical role of microRNAs in cancer. It examines how microRNAs can act as both oncogenes and tumor suppressors, and the implications of these findings for cancer therapy.

Animal Models to Study microRNA Functions

This chapter reviews the use of animal models in understanding microRNA functions and their role in cancer. It highlights the strengths and limitations of different model systems and discusses the translational potential of findings from these models.

Non-coding RNAs and Cancer

This comprehensive review covers the diverse roles of non-coding RNAs in cancer, including their involvement in tumorigenesis, metastasis, and drug resistance. It also discusses the therapeutic potential of targeting non-coding RNAs in cancer treatment.

microRNAs in Cancer Susceptibility

This section focuses on the genetic and epigenetic mechanisms underlying cancer susceptibility, with a particular emphasis on the contribution of microRNAs to these processes. It explores the potential of microRNAs as predictive biomarkers for cancer risk.

ts-RNAs versus microRNAs

This chapter compares and contrasts the functions and regulation of transfer RNA-derived small RNAs (ts-RNAs) and microRNAs in cancer. It highlights the distinct roles of these two classes of small RNAs and their implications for cancer biology and therapy.

microRNAs and AML

This review discusses the specific roles of microRNAs in acute myeloid leukemia (AML), including their involvement in leukemogenesis, disease progression, and treatment response. It also explores the potential of microRNAs as therapeutic targets in AML.

microRNAs and Epigenetics

This final chapter examines the interplay between microRNAs and epigenetic mechanisms in cancer. It discusses how microRNAs can influence epigenetic processes and how epigenetic modifications can, in turn, regulate microRNA expression and function.