Genetic Conditions Associated with Diabetes: A Comprehensive Guide

This volume, edited by renowned experts F. Barbetti, L. Ghizzoni, F. Guaraldi, M. Porta, F.M. Matschinsky, and others, provides a comprehensive overview of the genetic conditions associated with diabetes. The book is divided into five sections, each focusing on different aspects of genetic defects and their relationship with diabetes.

Section 1: Genetic Defects Involving the Pancreatic Beta Cell

This section delves into the genetic defects that affect the functioning of the pancreatic beta cell, leading to various forms of diabetes. It covers topics such as monogenic diabetes, including the neonatal form and Wolfram syndrome, and provides insights into the genetic mechanisms underlying these conditions.

Section 2: Extreme Insulin Resistance

This section explores the genetic conditions that result in extreme insulin resistance, a key factor in the development of type 2 diabetes. It discusses the genetic basis of insulin resistance and its implications for diabetes management.

Section 3: Ciliopathies and Diabetes

Ciliopathies are a group of genetic disorders that affect the structure and function of cilia, leading to a range of health problems, including diabetes. This section examines the relationship between ciliopathies and diabetes, shedding light on the genetic mechanisms involved.

Section 4: Obesity, Glucose Metabolism, and Chromosomal Defects

This section covers the genetic aspects of obesity and its impact on glucose metabolism, as well as chromosomal defects that can lead to complex conditions associated with diabetes, such as Trisomy 21 or Prader-Willi syndrome.

Section 5: Other Genetic Conditions and Diabetes

The final section of the book discusses other genetic conditions that can increase susceptibility to diabetes, including Friedreich’s ataxia and muscular dystrophy. It provides a detailed analysis of the genetic mechanisms underlying these conditions and their relationship with diabetes.

Target Audience: This book is a valuable resource for pediatric and adult endocrinologists and diabetologists, as well as researchers and healthcare professionals interested in the genetic aspects of diabetes.

Publication Details: The book is part of the Frontiers in Diabetes series, Volume 25, published by S. Karger in April 2017. It contains 192 pages and is available in hardcover format.