Epigenetic Mechanisms in Cancer: A Comprehensive Analysis

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression, and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification, which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volume offers a unique evaluation of signature differences in childhood, sex-specific, and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments.

Epigenetic Processes in Humans

Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications, and microRNAs (miRNAs) involved in the initiation, progression, and metastasis of tumors. Also delineated are recent technologies such as next-generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign, and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Applicability and Relevance

Offers broad coverage that is applicable to audiences in various areas of cancer research – population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management.

Expert Contributions

Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis. Features contributions by leading experts in the field. Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs.

Product Details

Series: Translational Epigenetics (Book 3) Hardcover: 392 pages Publisher: Academic Press; 1 edition (November 21, 2017) Language: English ISBN-10: 0128095520 ISBN-13: 978-0128095522 Product Dimensions: 7.5 x 0.8 x 9 inches