Precision Medicine in Neurodegenerative Disorders: Understanding the “Why” Behind Slowing Brain Aging

Edited by Alberto J. Espay, Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology, delves into the fundamental question of “why” we need to adopt a precision medicine approach to combat the progression of accelerated brain aging.

A Comprehensive Framework for Disease-Modifying Efforts

This volume provides a scholarly background on the framework, basic science, and conceptual pitfalls related to disease-modifying efforts in Parkinson’s, Alzheimer’s, and other neurodegenerative disorders. It covers various topics, including:

• Models of precision medicine and their applications
• The tension between lumping and splitting in biomarker development and therapeutics
• The rationale for replacing traditional autopsy-based nosology with a systems biology approach to human diseases

Genetic Subtypes and Lessons from Oncology and Cystic Fibrosis

Specific chapters are dedicated to the promise of genetic subtypes and the valuable lessons that can be learned from disease modification efforts in oncology and cystic fibrosis. These insights can be adapted to inform the field of neurodegeneration, enabling the development of more effective therapies.

The Vision of Precision Medicine: Matching Biology-Correcting Therapies with Suitable Patients

Precision medicine represents the highest level of personalized medicine, where the goal is to match biology-correcting therapies with patients who are biologically suitable to benefit from them. This vision and mission have the potential to revolutionize the treatment of neurodegenerative disorders.

Product Details:

• Publisher: Elsevier
• Edition: 1st edition (June 16, 2023)
• Language: English
• Hardcover: 288 pages
• ISBN-10: 0323855385
• ISBN-13: 978-0323855389