Alpha-1-Antitrypsin Deficiency: A Comprehensive Guide

By Andreas Rembert Koczulla

Alpha-1-antitrypsin (A1-AT) deficiency is one of the most common genetic defects in Europe. As a result of the reduced A1-AT serum level, there is a disruption in the proteinase-antiproteinase balance, which can lead to the early development of lung emphysema, among other issues. The underdiagnosis of A1-AT deficiency is also a significant problem. It is estimated that only about 5 to 15% of homozygous patients are currently identified. There is often a diagnostic delay of 5 years or more. This book provides an overview of the causes and genetics of this disease, as well as diagnosis and treatment, the role of comorbidities, and further topics such as vaccinations, sports, and physical activities, as well as the very complex aspects of lung transplantation. The increasing importance of imaging is also addressed, as is the clinical overall assessment and the need for follow-up examinations. The result is a very practice-oriented volume that will be very helpful in everyday clinical practice when caring for patients with A1-AT deficiency.

Product Details

Publisher: UNI-MED; 1st edition (8 April 2021)

Language: German

ISBN-10: 3837424162

ISBN-13: 978-3837424164