Sinusoidal Cells in Liver Diseases: Uncovering their Crucial Role in Pathophysiology, Diagnosis, and Treatment

Authored by Jordi Gracia-Sancho, BSc, PhD, this comprehensive reference provides a cutting-edge review of the latest advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases.

Role of Sinusoidal Cells in Liver Diseases: Pathophysiology, Mechanisms, and Therapeutic Targets

The book places a strong emphasis on disease pathophysiology, novel mechanisms, unmet clinical questions, biomarker development, and treatment opportunities, offering a thorough understanding of the role of sinusoidal cells in human liver diseases.

Coverage includes:

• Phenotypic changes occurring in liver vascular cells and their contribution to microcirculatory dysfunction, fibrosis, inflammation, and liver failure.
• The development of novel biomarkers of liver diseases that derive from sinusoidal cells.
• The identification of sinusoidal cells as key therapeutic targets to improve liver diseases.

A Comprehensive Update on Sinusoidal Cells in Liver Diseases

This reference provides a state-of-the-art overview of the role of sinusoidal cells in acute and chronic liver diseases, highlighting their importance in pathophysiology and mechanisms, as well as their potential as therapeutic targets and biomarkers.

With 562 pages of in-depth information, this book is an essential resource for researchers, clinicians, and students seeking to advance their understanding of liver diseases and the crucial role of sinusoidal cells in their pathophysiology, diagnosis, and treatment.

Publisher: Academic Press (1st edition, May 3, 2024)

Language: English

ISBN-10: 0323952623

ISBN-13: 978-0323952620