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Introduction: The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. This comprehensive guide reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures.
The concept of privileged structures has been evolving over the years, with significant contributions from various researchers in the field of medicinal chemistry. These structures have been instrumental in the discovery of new drugs and have played a crucial role in the development of several therapeutic agents.
This guide provides a practical compendium to privileged structures, detailing the synthetic routes to these structures. It covers a wide range of privileged scaffolds, including benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen.
This guide includes numerous, illustrative case studies that document the current use of privileged structures in the discovery of drugs. These case studies provide valuable insights into the application of privileged structures in various therapeutic areas, including but not limited to cardiovascular diseases, central nervous system disorders, and cancer.
The use of privileged structures in drug discovery is an evolving field, with new developments in organic chemistry continually expanding the range of accessible target molecules. This guide offers an informed perspective on the future direction for the field, highlighting potential areas of growth and opportunities for innovation.
This comprehensive guide is designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty. It provides a valuable resource for anyone working in the field of drug discovery or interested in learning more about the role of privileged structures in medicinal chemistry.
This guide offers the following key features:
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