The Handbook of Metabolic Phenotyping: A Comprehensive Guide

Edited by renowned experts in the field, John C. Lindon, Jeremy K. Nicholson, and Elaine Holmes, The Handbook of Metabolic Phenotyping is a seminal work on the rapidly evolving subject of metabolic phenotyping. This book provides a detailed exploration of the various analytical chemistry and statistical modeling techniques employed in the field, coupled with comprehensive surveys of application areas in human development, nutrition, disease, therapy, and epidemiology.

It delves into recent studies that integrate multiple -omics data sets to derive a systems biology view, addressing current issues on standardization, assay and statistics validation, and data storage and sharing. As pioneers in the field, the editors have many years of practice and have developed approaches widely used today, making this handbook an invaluable resource for postgraduates and research scientists studying and advancing the field of metabolomics.

Comprehensive Coverage of Analytical Chemistry Techniques

The Handbook of Metabolic Phenotyping offers theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping, including but not limited to:

• Mass spectrometry
• Nuclear magnetic resonance spectroscopy
• Chromatography
• Electrophoresis

Diverse Statistical Approaches

The handbook also explores, in detail, the many diverse statistical approaches used in the field, such as:

• Univariate and multivariate statistical analysis
• Machine learning algorithms
• Bayesian statistics
• Meta-analysis

Practical Tips for Successful Studies

Featuring practical tips for successfully conducting metabolic phenotyping studies, this book serves as a guide for researchers navigating the complexities of study design, data collection, and data analysis.

Reviews of Various Fields of Activity

The Handbook of Metabolic Phenotyping includes reviews of all the various fields of activity relating to human studies, encompassing:

• Metabolomics in disease diagnosis and monitoring
• Nutritional and environmental influences on metabolic phenotype
• Pharmacometabolomics and personalized medicine
• Metabolic phenotyping in epidemiological studies

With its comprehensive coverage of analytical techniques, statistical approaches, and practical applications, The Handbook of Metabolic Phenotyping is an essential resource for anyone involved in the study of metabolomics.