Unlocking the Secrets of Chromatin Readers in Health and Disease

With the latest release in the Translational Epigenetics series, Chromatin Readers in Health and Disease, Volume 35, renowned author Olivier Binda sheds light on the crucial role of chromatin readers in regulating access to genetic information and their implications in human pathologies.

Understanding Chromatin Readers and Their Regulation

This comprehensive book delves into the world of chromatin readers, covering a range of proteins that play a vital role in gene expression. Explored in-depth are 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.

The Impact of Chromatin Readers on Human Disease

More than a dozen leading experts in the field examine the intricate relationship between chromatin readers and human disease, including their role in the development and progression of cancers and Huntington’s disease. The book also explores early therapeutics that target chromatin signaling factors, offering promising solutions for the treatment of various disorders.