The Regulatory Genome: Unlocking the Secrets of Adaptation, Evolution, Development, and Disease

Author Moyra Smith’s groundbreaking book, The Regulatory Genome in Adaptation, Evolution, Development, and Disease, delves into the intricate world of gene regulation, exploring its crucial role in adaptive evolution, developmental biology, and disease susceptibility across various organisms, from humans to plants, animals, and single-cell life.

A Comparative Approach to Gene Regulation

This comprehensive volume adopts a unique comparative approach, synthesizing insights from recent genomic and gene expression studies across species to reveal common evolutionary themes and genome diversity. By examining gene regulation across evolutionary timelines, the book sheds light on new areas of focus and future research directions.

Key Elements in Gene Expression Regulation

The book provides an in-depth exploration of key elements in gene expression regulation, including:

• Foundations of genomic alterations over time and in response to environmental and local conditions
• Epigenetics in adaptive evolution
• Adaptive gene regulation in healthy processes and developmental biology
• Adaptive gene regulation in disease biology

Unraveling the Secrets of Human Adaptive Evolution

By adopting a cross-species view, the book highlights common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies. This facilitates a deeper understanding of human adaptive evolution and its implications for disease outcomes and healthy human metabolism, development, and physiology.

Impact on Disease Outcomes and Human Health

The book concludes by detailing the potential applications of this knowledge in improving disease outcomes and promoting healthy human metabolism, development, and physiology. This valuable resource is essential reading for researchers, scientists, and students seeking to unravel the complexities of gene regulation and its far-reaching implications.

Book Details

Publisher: Elsevier Science

Publication Date: March 10, 2023

Language: English

ISBN: 9780443153525, 9780443153532