Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2

By Karam F.A. Soliman, Yashwant V. Pathak

The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the cellular antioxidant response. It plays a critical role in various biological functions such as cell viability, metabolism, autophagy, inflammation, immunity, and differentiation. Nrf2 regulates over 600 genes and is known to alleviate oxidative stress, which is a key factor in many pathologic processes including aging, obesity, diabetes, cancer, and neurodegenerative diseases.

Flavonoids, through their ability to activate and upregulate Nrf2, possess anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. They are essential ingredients in nutraceuticals, functional foods, and pharmaceuticals. This book focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative diseases.

Key Features:

– Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and “WELLNESS” molecule

– Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals

– Presents flavonoid-based functional foods

– Discusses the flavonoid nutraceuticals market and future trends

– Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

Product Details:

– Publisher: CRC Press; 1st edition (May 3, 2023)

– Language: English

– Hardcover: 278 pages

– ISBN-10: 1032113731

– ISBN-13: 978-1032113739