Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor 2

By Karam F.A. Soliman, Yashwant V. Pathak

The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key player in the cellular antioxidant response. It is a master regulator that controls over 600 genes, influencing critical biological functions such as cell viability, metabolism, autophagy, inflammation, immunity, and differentiation. Oxidative stress, which Nrf2 can mitigate, is a significant contributor to various pathologic processes, including aging, obesity, diabetes, cancer, and neurodegenerative diseases.

Flavonoids, a class of plant-derived compounds, have been shown to activate and upregulate Nrf2, thereby possessing anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. These compounds are essential ingredients in nutraceuticals, functional foods, and pharmaceuticals. The book “Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor 2” delves into the interaction between Nrf2 and flavonoids, exploring their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative diseases.

Key Features

• Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and “WELLNESS” molecule
• Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals
• Presents flavonoid-based functional foods
• Discusses the flavonoid nutraceuticals market and future trends
• Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

Product Details

Publisher: CRC Press; 1st edition (May 3, 2023)
Language: English
Hardcover: 278 pages
ISBN-10: 1032113731
ISBN-13: 978-1032113739