Molecular, Cellular, and Metabolic Fundamentals of Human Aging: Uncovering the Complexities of Aging

Authored by Evandro Fei Fang, this comprehensive guide delves into the intricacies of human aging, providing researchers with a thorough understanding of the underlying mechanisms and physiology that contribute to age-related diseases and conditions.

Unraveling the Aging Process: Key Mechanisms and Pathways

The book explores various hallmarks of aging, including:

• DNA damage and ineffective repair, leading to cell and tissue aging and decreased functionality
• Loss of proteostasis and its impact on cellular health
• Changes to feeding and fasting pathways and their role in aging
• Mitochondrial dysfunction and its consequences
• The significance of autophagosomes and autophagy in aging
• Cellular senescence and its implications for aging
• Alterations to communication molecules and their effects on aging
• Stem cell exhaustion and its role in the aging process

Aging and Disease: The Complex Interplay

The book also examines the intricate relationship between aging and various diseases, including:

• Cancer: understanding the role of aging in carcinogenesis and tumor progression
• Neurodegenerative conditions: exploring the connections between aging and diseases such as Alzheimer’s

Emerging Concepts and Future Directions

The author considers the dialogue surrounding the topic of aging beyond basic biology, including:

• NAD+ depletion: its emerging role in human aging and potential therapeutic implications
• Defective autophagy: its significance in aging and age-related diseases

By covering the fundamental hallmarks of aging and their relevance to various diseases, this book provides a comprehensive understanding of the complexities of human aging.

Key Features:

• Covers the basic hallmarks of aging and their relevance in various diseases
• Discusses the impact of genetic damage and changes in genetic expression patterns on the aging process
• Highlights recurring themes and key principles shared across the hallmarks of aging

Published by Elsevier Science in October 2022, this book is a valuable resource for researchers and scientists seeking to understand the intricacies of human aging.