Molecular, Cellular, and Metabolic Fundamentals of Human Aging: Unraveling the Mysteries

Delve into the intricacies of human aging with this comprehensive guide, expertly crafted by Evandro Fei Fang. “Molecular, Cellular, and Metabolic Fundamentals of Human Aging” presents a thorough overview of the primary mechanisms and physiology driving the aging process, shedding light on how they contribute to age-related diseases and conditions.

Aging Mechanisms and Physiological Changes

The book explores a wide range of topics, including:

• DNA damage and the consequences of inefficient repair on cellular and tissue aging
• The loss of proteostasis and its impact on cellular function
• Changes to feeding and fasting pathways and their effects on metabolism
• Mitochondrial dysfunction and its role in aging
• The implications of decreased autophagy and autophagosomal function
• Cellular senescence and its contribution to aging
• Alterations to communication molecules and their impact on cellular interactions
• Stem cell exhaustion and its consequences for tissue regeneration

The Immune System and Age-Related Diseases

The book also delves into the complex relationship between aging and the immune system, examining how aging contributes to diseases such as:

• Cancer
• Neurodegenerative conditions, including Alzheimer’s disease

In addition, the book provides an in-depth exploration of the ongoing dialogue surrounding aging, moving beyond basic biology to consider the broader implications of this complex process.

Key Takeaways

This comprehensive guide highlights the recurring themes and key principles shared across the hallmarks of aging, including:

• The impact of genetic damage and changes in gene expression patterns on the aging process
• The emerging roles of NAD+ depletion and defective autophagy in human aging

By covering the basic hallmarks of aging and their relevance in various diseases, this book provides a thorough understanding of the complex interplay between aging, physiology, and disease.