Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease

By Kenneth Maiese (Author), this book provides a comprehensive analysis of sirtuins in the body during normal physiology and disease, highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension.

Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders.

Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease. This book details the basic and clinical role of sirtuins for the development of new clinical treatments, summarizing the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body.

This book serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings. It provides a comprehensive overview of the role of sirtuins in health and disease, making it an essential read for those interested in the field of sirtuin biology and its implications for medicine.

Published by Elsevier Science on March 4, 2021, this book is available in English. The ISBN for the hardcover edition is 9780128141182, and for the e-book edition, it is 9780128141199. This book is a valuable addition to any library, providing cutting-edge information on the role of sirtuins in medicine and their potential applications in the treatment of various diseases.