Blood and Marrow Transplantation Long-Term Management: A Comprehensive Guide to Survivorship after Transplant

Hematopoietic cell transplantation (HCT) has revolutionized the treatment of various diseases, offering a curative therapy for hematologic malignancies and non-malignant disorders. Over the years, significant advancements have been made in the field of HCT, making it an integral part of treatment modalities.

The Evolving Landscape of HCT

Factors such as expanded disease indications, greater donor options, and accommodations for older and less fit recipients have driven the growth of HCT. The development of less toxic pre-transplant conditioning regimens, improved prophylaxis of graft-versus-host disease (GVHD), and enhanced infection control have resulted in a growing number of transplant recipients surviving long-term, free of disease.

The Changing Demographics of Transplant Recipients

The composition of the long-term survivor population has shifted over time, with an increasingly older transplant recipient cohort and a shift in transplant indications. Changes in cell source, donor types, conditioning regimens, and supportive care have all contributed to ongoing reductions in both relapse and non-relapse mortality (NRM).

The Risks of Late Complications

Long-term survivors of HCT are at increased risk for a variety of late complications, which can significantly impact quality of life and mortality. It is essential for healthcare providers to be aware of these potential complications and provide specialized monitoring and management to mitigate their effects.

The Importance of Preventive Care and Early Detection

Preventive care, early detection, and timely treatment are critical in reducing morbidity and mortality in long-term survivors after allo-HCT. This requires a comprehensive understanding of the diagnosis, screening, treatment, and long-term surveillance of late complications.

The second edition of “Blood and Marrow Transplantation Long-Term Management: Survivorship after Transplant” provides up-to-date information on the management of long-term survivors after HCT, focusing on the identification and treatment of late complications that affect quality of life and long-term morbidity and mortality.

Product Details:

• Publisher: Wiley
• Publication Date: March 2, 2021
• Language: English
• ISBN: 9781119612698, 9781119612742