Understanding von Willebrand Disease and Syndrome: Causes, Diagnosis, and Treatment

Von Willebrand disease and syndrome are two distinct medical conditions characterized by varying degrees of bleeding tendencies. Both conditions are associated with significant impairments in primary hemostasis and often, blood coagulation as well. The root cause of these conditions lies in quantitative and/or structural defects of the von Willebrand factor (VWF).

The Prothrombotic Side of von Willebrand Factor

In contrast, the prothrombotic aspect of VWF can lead to severe thrombo-embolic events in the context of thrombotic thrombocytopenic purpura, especially when its regulatory function is impaired by the protease ADAMTS13.

Current Insights into von Willebrand Factor Function and Regulation

Recent advancements in understanding the function and regulation of VWF have significant implications for the diagnosis and treatment of VWF-associated diseases. These molecular-genetic findings have been updated and summarized here. Moreover, the prothrombotic aspect of VWF has been the focus of intense research in recent years, yielding promising therapeutic options for patient care.

This comprehensive publication provides expert insights into the pathogenesis of VWF-associated diseases, their molecular-genetic basis, and the latest diagnostic and therapeutic approaches. Published by UNI-MED Verlag AG, this fourth edition is a valuable resource for healthcare professionals and researchers alike.

Book Details:

• Publisher: UNI-MED Verlag AG
• Edition: 4th edition
• Language: German
• ISBN-10: 3837416119
• ISBN-13: 978-3837416114