Optimizing CNS Drug Discovery: Overcoming the Blood-Brain Barrier Challenge

Edited by renowned experts Li Di and Edward H. Kerns, this comprehensive guide focuses on central nervous system (CNS) drug discovery, providing researchers with the knowledge to improve brain penetration and minimize CNS side-effects.

Practical Solutions for Breaking Down the Blood-Brain Barrier

With contributions from world-leading experts, this book offers practical solutions to increase brain penetration, covering:

• State-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration
• Advanced CNS drug delivery strategies
• BBB physiology and medicinal chemistry design principles
• The free drug hypothesis for the BBB and transport mechanisms, including passive diffusion, uptake/efflux transporters, and receptor-mediated processes

The book also delves into the latest advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK).

Success Stories and Lessons Learned

Through real-life case studies of successful CNS and non-CNS drugs, readers can gain valuable insights into the challenges and opportunities in CNS drug discovery, as well as the paths to market for these drugs.

With 616 pages of comprehensive information, this valuable resource is essential reading for anyone involved in CNS drug discovery and development.

ISBN-13: 9781118788356 | Publisher: Wiley | Publication date: February 9, 2015 | Edition: 1