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Fast Facts: Systemic Mastocytosis (Original PDF from Publisher)

Systemic Mastocytosis (SM): A Rare Hematologic Neoplasm

Systemic Mastocytosis (SM) is a rare and complex group of hematologic neoplasms characterized by the clonal proliferation of mast cells in the bone marrow and extracutaneous organs. This clonal proliferation can lead to symptoms caused by mast-cell mediator release and end-organ damage resulting from mast-cell infiltration.

Classification and Epidemiology

The World Health Organization (WHO) recognizes mastocytosis as a distinct entity due to its unique clinicopathological features. In fact, over 95% of patients with SM harbor the somatic KIT driver mutation D816V. The epidemiology of SM is not fully understood, but research suggests that it affects a small percentage of the global population.

Diagnosis and Management Challenges

The diagnosis of SM can be challenging, and patients may present to various healthcare providers on their diagnostic journey. This book provides up-to-date, practical guidance on the diagnosis and management of patients with SM, addressing the clinical, diagnostic, and management challenges associated with this complex condition.

Comprehensive Coverage of SM

This comprehensive guide covers essential topics, including:

  • Definitions and classification of SM
  • Epidemiology and pathophysiology of SM
  • Diagnosis of SM, including laboratory tests and imaging studies
  • Management of non-advanced systemic mastocytosis
  • Management of advanced systemic mastocytosis
  • Future directions in SM research and treatment

This invaluable resource is designed for clinicians, medical students, nurses, pharmacists, and scientists seeking to understand the complexities of SM and provide optimal care for patients with this rare condition.

Publication Details:

Published by S. Karger Publishing on December 31, 2022, this 104-page paperback book is an essential addition to any medical library. The ISBN-10 is 3318071617, and the ISBN-13 is 978-3318071610.

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