Low-Grade Glioma: A Comprehensive Overview

This issue of Neurosurgery Clinics, expertly curated by Drs. Guy McKhann and Hugues Duffau, with the valuable input of consulting editors Russell R. Lonser and Daniel K. Resnick, delves into the intricacies of Low-Grade Glioma. The topics encompassed in this edition include, but are not limited to:

Epidemiology and Molecular Epidemiology

A detailed exploration of the incidence, prevalence, and molecular aspects of low-grade gliomas, shedding light on the genetic and environmental factors that contribute to their development.

WHO Pathological and Molecular Classification

A comprehensive review of the World Health Organization’s classification of low-grade gliomas, including their pathological and molecular characteristics, and how these classifications impact treatment strategies.

Molecular Pathogenesis

Insights into the molecular mechanisms underlying the formation and progression of low-grade gliomas, highlighting potential therapeutic targets for future treatments.

Glioma Cell Migration and Heterogeneity

A discussion on the migratory patterns of glioma cells and the heterogeneity within these tumors, which significantly influences treatment outcomes and patient survival.

Clinical Presentation, Natural History, and Prognosis

A thorough examination of how low-grade gliomas present clinically, their natural course, and the factors that determine patient prognosis, aiding in the development of personalized treatment plans.

LGG Epilepsy

Exploration of the relationship between low-grade gliomas and epilepsy, including the impact of tumor location and size on seizure activity and the role of surgery in seizure control.

MRI, fMRI, DTI, Molecular Imaging

A review of the various imaging modalities used in the diagnosis and monitoring of low-grade gliomas, including magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion tensor imaging (DTI), and molecular imaging techniques.

Brain Mapping Techniques in LGG

A detailed look at the brain mapping techniques employed to identify eloquent areas during surgery for low-grade gliomas, ensuring maximal tumor resection while preserving critical brain functions.

Surgical Adjuncts to Increase EOR

A discussion on the surgical adjuncts available to enhance the extent of resection in low-grade glioma surgery, such as intraoperative MRI, fluorescence, and Raman histology.

Mapping Cognition and Emotion

Investigation into the methods used to map cognitive and emotional functions in the brain, crucial for preserving quality of life in patients undergoing surgery for low-grade gliomas.

Extent of Resection

Analysis of the impact of the extent of resection on patient outcomes in low-grade glioma surgery, highlighting the delicate balance between tumor removal and preservation of brain function.

EOR vs Molecular Classification

A comparison of the extent of resection and molecular classification in determining patient prognosis and treatment response in low-grade gliomas.

Chemotherapy Treatment and Trials

A review of the chemotherapy options available for low-grade gliomas, including ongoing clinical trials and the challenges associated with treating these tumors.

Radiotherapy Treatment and Trials

Examination of the role of radiotherapy in the management of low-grade gliomas, including the various treatment protocols and the results of recent clinical trials.

Higher Order Surgical Questions

Exploration of the complex surgical questions that arise in the treatment of low-grade gliomas, including the timing of surgery, the role of awake craniotomy, and the management of tumor recurrence.

Building a Glioma Practice

Practical advice for establishing and maintaining a successful practice focused on the treatment of low-grade gliomas, including the importance of multidisciplinary collaboration and staying current with the latest research and advancements.