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The publication of this latest Fascicle marks a significant shift in the diagnosis of lower genital tract lesions, transitioning from a primarily morphologic approach to an integrated assessment that combines microscopy and molecular biology. This fusion of diagnostic tools enables a more comprehensive understanding of patient cases and allows for more effective disease management.
The introduction of prophylactic vaccines for preventing human papillomavirus (HPV) infections and cervical cancer precursors has also thrust pathology into a critical public health role, emphasizing the importance of disease monitoring and prevention. As cervical cancer becomes increasingly preventable, the focus is now on translating this achievement into a achievable goal of cancer prevention in underdeveloped nations.
This revised edition of the Fascicle has been substantially updated to reflect the significant advancements in the field since its previous publication in 1992. The number of illustrations, all of which are in vibrant color, has nearly doubled, providing a more detailed and accurate visual representation of lower genital tract lesions.
Both the text and photomicrographs place a strong emphasis on the importance of immunohistochemistry and molecular in situ hybridization as essential adjuncts to morphology in routine clinical diagnosis. A binary classification system for histology, analogous to TBS for cytology, has replaced the four-tiered dysplasia/CIS system and the three-tiered CIN system, providing a more streamlined and efficient approach to diagnosis.
This Fascicle is an indispensable reference for pathologists, residents, and students, offering a comprehensive and authoritative guide to the diagnosis and management of lower genital tract lesions. With its concise yet detailed approach, this resource is poised to remain a valuable tool for years to come.
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