Unlock the Secrets of Macrophages: A Comprehensive Guide to Their Biology and Therapeutic Potential

Recent research has led to significant breakthroughs in understanding the biology of macrophages, highlighting their crucial role in the human body. Beyond their initial response to pathogens, macrophages exhibit distinct characteristics across various tissues, organs, and systems.

The Diverse Functions of Macrophages

Macrophages are a heterogeneous population of phagocytic cells, possessing a wide range of phenotypes and tissue-specific functions. These include bone resorption, extracellular matrix production, removal of red blood cells and bacteria, and more. Through innate immune receptors, macrophages modulate multiple pathways, resulting in the production of various inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators.

Environmental signals can also modify and induce metabolic reprogramming, altering the phenotype and functions of macrophages. This complex interplay has significant implications for our understanding of human health and disease.

Exploring the Diversity of Macrophages Across Human Body Systems

The book “Macrophages in the Human Body: A Tissue Level Approach” presents a comprehensive overview of macrophage diversity across multiple human body systems, including their phenotype, function, and metabolic characteristics. By exploring the translational aspects of macrophage biology, this book highlights the therapeutic potential of these cells.

Aims and Scope

• Presents a current overview of the diversity of macrophages across multiple human body systems
• Covers their phenotype, function, and metabolic characteristics
• Introduces macrophages generally and delves into organ/tissue-specific representations
• Brings updated aspects of macrophage biology, highlighting therapeutic potential

Published by Elsevier Science, this book is a valuable resource for researchers, scientists, and healthcare professionals seeking to understand the complex biology of macrophages and their potential applications.

Publication Details:

• Language: English
• Publication Date: June 8, 2022
• ISBN: 9780128213858, 9780128213865