Mammalian Heme Peroxidases: Understanding Their Role in Innate Immunity and Chronic Inflammatory Disease

By Clare Hawkins, a renowned author in the field of biochemistry, this book delves into the critical role of mammalian heme peroxidase enzymes in innate immune responses and disease prevention. It highlights the formation of potent chemical oxidants, which is essential for protective physiologic activity in immunity.

Chemistry and Biochemistry of Mammalian Peroxidases

The book provides an in-depth analysis of the structure and biosynthesis of mammalian peroxidases, shedding light on the reactivity of hypohalous acids with biological substrates. This information is crucial for understanding the diverse roles of mammalian heme peroxidases in both innate immunity and chronic inflammatory diseases.

The Role of Peroxidases in Innate Immunity

Clare Hawkins emphasizes the importance of peroxidases in innate immunity, detailing how these enzymes contribute to the initiation and persistence of many chronic inflammatory conditions in various end organs. This insight is vital for researchers and medical professionals seeking to understand the complex interplay between peroxidases and the immune system.

Peroxidases in Human Pathology

The book also explores the involvement of peroxidases in human pathology, covering a range of diseases affecting different organ systems, including the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. This comprehensive overview helps readers appreciate the breadth and incidence of pathologies associated with these enzymes.

Modulating Peroxidase Activity as a Therapeutic Strategy

Given the significant interest in modulating peroxidase activity as a therapeutic strategy, the book discusses potential approaches to prevent damaging reactions. This section is particularly relevant for researchers and clinicians investigating new treatments for chronic inflammatory diseases.

Key Features:

• Structure and biosynthesis of mammalian peroxidases
• Reactivity of hypohalous acids with biological substrates
• Peroxidases in innate immunity
• Peroxidases in human pathology
• Modulation of peroxidase-induced biological damage